With the increasing prevalence of diseases, the growing awareness, and rising government initiatives for the same, the pharmaceutical industry is growing. With emerging product lines, and new technologies over the past decade and especially the past two years, the pharmaceutical industry has undergone revolutionary changes. One sector, particularly, on a steady rise is pharmaceutical sprays. Most pharmaceutical companies today are also labeling them as pharmaceutical sprays manufacturers in aid to create effective solutions to the health and wellness issues of their customers and increasing lifestyle pharmaceutical product needs.
Pharmaceutical sprays are medicines that are administered nasally or orally to the patient through respiration. In pharmaceutical sprays, a solid or liquid form is converted into a dynamic mixture dispersed in gas form through atomization. This atomized spray can be directly used onto the skin for fast relief and systematic medicinal effects. Let us know more about pharmaceutical sprays!
Pharmaceutical sprays – The Production process
Let us go through the major process steps associated with the manufacture of pharmaceutical sprays.
- Mixing: The first step in the manufacture of pharmaceutical sprays is mixing the ingredients. A pharmaceutical sprays manufacturer mixes the API or the active pharmaceutical ingredient and additional active ingredients or solvents into a concentrate. Depending upon the phase of ingredients and the process conditions, various types of mixers are used in pharmaceutical spray manufacturing depending upon the purpose of the product.
- Spray Filling: Once the APIs or the active pharmaceutical ingredients are mixed into a spray concentrate, the process moves on to the filling step. The solid or liquid concentrate is moved into an appropriate spray device for the administration of the drug. In spray filling, the spray concentrate is pumped into the spray device, which will atomize it during drug administration. Most spray filling processes use standard transport and storage equipment to handle and fill spray devices with the accurate dosage of the concentrate. The handling and transport of the concentrates are commonly done using pumps, pipes, and tanks, and the spray devices are transported to filling locations via conveyors.
- Aerosol Filling: Aerosols are specialized spray devices with the filling step requires more complicated processes and equipment. They contain pharmaceutical concentrate as well as substances that are gases at standard temperature and atmospheric pressure, known as propellant chemicals. Propellants pressurize the spray device to expel the drug properly upon administration. Rotary machines can be used to fill the aerosols via the process of pressure filling as well as cold filling. During pressure filling, liquefaction and transfer of the propellant into the spray device are done under high pressure causing the entire spray bottle to become pressurized on evaporation of the propellant. This allows for the proper dispensing of the pharmaceutical on the usage of the spray device. During cold filling, liquefaction of the propellant is done at a very low temperature followed by transferring the liquid propellant into a spray device. When the temperature is ambient, the propellant vaporizes and pressurizes the spray device allowing for proper dispensing of the pharmaceutical on the usage of the spray device.
Types of pharmaceutical sprays
During the process of spray filling in the pharmaceutical sprays manufacture, spray devices are filled with the pharmaceutical concentrate. These specialized pieces of equipment atomize the concentrate upon administration. The different types of spray devices may include:
- Spray Bottles: Spray bottles consist of a container and fixture. The fixture acts as a pump and has a nozzle at the top with a tube that extends to the bottom of the bottle. On pressing the fixture, the concentrate draws up the tube and travels through the nozzle. On passing through the nozzle, the concentrate atomizes into smaller particles and is dispersed in the air creating a spray. From disinfectant sprays to muscle pain relief sprays there are a range of product that are today administered as pharmaceutical sprays.
- Aerosols: Aerosols are specialized kind of spray devices. They contain concentrates as well as propellants. Propellants are liquefied gas substances that maintain suitable pressure and pressurize the aerosol upon vaporization.
- Nebulizers: Nebulizers are stationary, box-shaped devices. In nebulizers, the concentrate is filled directly from the storage device into the spray device before use. Ultrasonic and air-jet are the two types of nebulizers. Ultrasonic nebulizers vibrate the internal concentrate at a high frequency to create a mist. Air-jet nebulizers, on the other hand, feed pressurized air into the nebulizer. The pressurized air then mixes with the concentrate to create a mist. In both the nebulizers, the spray then travels through a tube extending from the device to the point where the patient can inhale the spray medicine. Nebulizers are usually used in delivering medicine to the respiratory system in hospitalized patients or for at-home use.
- Dry Powder Inhalers: DPIs or Dry powder inhalers are a variant of pharmaceutical sprays that deliver medicine to the respiratory system in the form of a dry powder. These are disk-like devices containing an internal, coiled strip with pockets containing one dose of the powdered medicine. The user administers the drug by inhaling it through the mouthpiece. After each usage, the coil rotates through the device. An external lever is pushed causing the lining up of one pocket of powder with the mouthpiece.
Uses of pharmaceutical sprays
Pharmaceutical sprays manufacturers have aided the growth of pharmaceutical sprays because of the potential of the technology in finding effective solutions in drug storage and administration. Some of the most common uses of pharmaceutical sprays in the pharmaceutical industry are mentioned below.
- Spray bottles are often used in nasal decongestant sprays.
- Pharmaceutical aerosols are commonly used in inhalers commonly used as portable spray treatments for bronchitis, COPD and asthma.
- Nebulizers are often used for treating asthma, cystic fibrosis, and other long-term respiratory diseases.
- Dry powder inhalers or DPIs are commonly used to deliver powdered medicine for bronchitis, asthma, and other respiratory diseases as well as for inhalable insulin to treat diabetes.
In addition to these, there are various other ways pharmaceutical sprays are being used to provide efficient and effective solutions in pharmaceutical storage and administration. A good example of this is the ayurvedic spray oils that help in providing effective relief from different kinds of body aches and pains.
Advantages of pharmaceutical sprays
The popularity of pharmaceutical sprays in the pharmaceutical industry, as well as other industries, owes to the various advantages of the technology. They are as follows:
- Easy and direct Application: Pharmaceutical sprays provide for a rapid process of administering medicine. One only needs to spray the medicine to administer it. It also aids in the direct application or administration of the drug to the affected area or required inhalation point.
- Efficient And Quick Relief: Pharmaceutical sprays cause the direct application of the drug at the required area in the form of a mist causing efficient and quick absorption of the medicine to bring rapid relief to the patient.
- Stability Of Drug: The storage of the drug in pharmaceutical sprays prevents it from coming in contact with atmospheric oxygen and moisture. This prevents any possible contamination of the drug and enhances its stability.
- Sterile Dosage: Pharmaceutical sprays can be designed to dispense a required amount of drug on each spray. This causes the sprays to dispense a sterile dosage of the right amount of drug every time.
- Portability: The technology and design of pharmaceutical sprays help in avoiding any leakage or spillage of medicine that one might face in the traditional way of medication administration. This makes it easy for one to carry the medicines in the form of pharmaceutical sprays on the go without worrying about any spillage mishaps and issues.
Now that you know how pharmaceutical sprays are made and how they can be useful in transforming our perception of health and wellness in our daily life, it’s time to give it a try! From orthopain to foot care and other ayurvedic spray oils – Advait Pharmasol has a range of pharmaceutical sprays perfect to fit into your wellness routine!